Imaging pain and neurodegeneration: from cortical to subcortical
疼痛成像和神经退化:从大脑皮层到皮层下
孔亚卓   
报告人照片   孔亚卓,毕业于中国科技大学自动化系,于英国谢菲尔德大学心理学系获博士学位,现为牛津大学功能脑成像中心(FMRIB)资深研究员(Senior Research Fellow). 主持开发了去除fMRI生理噪声的方法,研发的工具包被集成到国际知名的FSL软件包中;主持开发和优化了脊髓fMRI成像和分析的步骤,该技术和分析方法居于国际领先水平,并首次发现在脊髓中也存在符合生理特性分布的静息态网络,此项成果发表在PNAS上,并被《自然》杂志网站报道。近年来,他致力于运用多模态磁共振成像,包括结构成像、fMRI、弥散张量成像(DTI)、动脉血标记灌注成像(ASL)、磁共振波普(MRS)等方法,来研究神经退行性疾病(如多发性硬化症和视神经脊髓炎)和长期慢性疼痛等。成功入选2016年度中科院率先行动“百人计划”技术英才,将到心理所磁共振成像研究中心开始研究工作。
  Pain-associated brain regions are collectively known as the “pain network” including both cortical areas and subcortical areas (most importantly, brainstem and spinal cord). Descending systems originating in the brainstem exert top-down modulation of nociceptive input at the spinal level. However these are challenging regions for imaging. The main difficulties are the small anatomical size; magnetic susceptibility differences (i.e. bone/disc interfaces); physiological noise - primarily cardiac and respiratory related; motion and flow artifacts due to cerebrospinal fluid (CSF) pulsation. In this talk, I will briefly discuss the concept of the pain mechanism and the current developments of brainstem and spinal fMRI, including some experiments we have run, such as laterality, attention and resting state networks in the spinal cord. I will discuss our latest quantitative MR techniques to study neurodegeneration at the end.
报告时间:2016年12月13日14时30分    报告地点:西区电二楼208会议室
报名截止日期:2016年12月13日    可选人数:50